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DNA isolation was performed using the QIAamp DNA FFPE tissue kit (Qiagen, Courtaboeuf, France) protocol.
According to the ERSPC France protocol, the decision to biopsy was based on clinical judgment following additional work-up such as DRE or additional PSA test.
Experiments performed in Tours, France (protocol registration 2012-11-9) were approved by the ethics committee CEEA VdL and were carried out according to French legislation (French Government Decree 2001 464) and EEC regulations (86/609/CEE).
After obtaining approval from the local ethics committee (Comité de Protection des Personnes Sud-Ouest et Outre Mer III, Bordeaux, France; protocol no. DC 2009/34) and informed consent from the patient's next of kin, 67 consecutive mechanically ventilated patients from our ICU were prospectively included in the study.
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The Ethics Committee of Kremlin-Bicêtre hospital in France France (Comité de Protection des Personnes Île-de-France VII) approved the protocol on January 9 , 1995
The protocol of the CoPanFlu-France study was approved by the research ethics committee "Comité de Protection des Personnes Ile-de-France 1" on September 8 , 2009
The appropriate French regulatory and ethical authority (Comité de Protection des Personnes Ile-de-France 6, La Pitié-Salpêtrière, Pitié-Salpêtrière, Paris approvedecisionotocol, and written informed consent was obtained from all patients.
This study protocol was approved by the Institutional Review Board, the Ile de France IX ethic committee on November 2011 and the AFSSAPS (Agence Française de Sécurité Sanitaire des Produits de Santé) on September 2011 under the registration number A110936-41.
The protocol was approved by the ethical committee (CPP Ile de France V).
The protocol was approved by the appropriate ethics committee [CPP Ile-de-France I, Paris, France, approval April, the 20 April 2013 13213].
The study protocol was approved by the ethics committee Comité de Protection des Personnes Ile de France XI and was registered with ClinicalTrials.gov (Identifier NCT00774774).
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