On a broader scale, through the use of Pol β we continue to develop a more precise understanding of the basis of DNA polymerase fidelity by establishing our techniques as a systematic framework of investigation that can be applied to multiple polymerases and additional site-specific mutants (42) during both matched and mismatched nucleotide incorporations.
Purpose of this report is to use nonlinear state-space models as a general framework for investigation of dynamics of biochemical networks and formulate the estimation of parameters in biochemical networks as a recursive nonlinear state estimation problem.
Our findings have identified regions of the genome that influence vitamin E biochemical status and provide a framework for investigation of this membrane-integrated micronutrient that is important in complex chronic diseases, such as cardiovascular disease, diabetes, and cancer.
In this perspective, we provide a conceptual framework for investigation of feeding behavior in this species, with an emphasis on factors that influence study design, data interpretation, and relevance to feeding behavior in humans.
Two types of experiments were performed in the framework of our investigation.
In the framework of our investigation, saturating concentrations were used to activate all the Bk receptors on the motoneurons.
Although there have been extensive studies over the past decade in the synthesis and application of metal-organic frameworks (MOFs), investigation of their thermodynamic stability and of the energetics of guest host interactions has been much more limited.
Within the framework of these investigations, two different types of tile stoves were tested: a single-walled stove without an air gap and a double-walled stove with an air gap.
The device now makes it possible to carry out nondestructive emission testing on surfaces within the framework of field investigations.
