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In our modelling pipeline we utilised three modelling frameworks in sequence to fully exploit the available data and investigate different aspects of the system on appropriate levels of abstraction.
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In this perspective piece we intend both to provide a framework in which to think about future DNA sequence archiving and to provide an initial opinion with concrete examples to encourage appropriate debate in the community.
Here, we report a unified statistical framework similar to that used in sequence and structure comparison (Levitt and Gerstein, 1998) where the significance of binding-site similarity can be estimated at least two orders of magnitude faster than for the original non-parametric method.
Besides HHpred and HHalign, HHsenser may be useful here as it allows intermediate HMM-HMM hits in the same framework to cover greater distances in sequence space (e.g. if starting alignment created by HHpred for a query has too few sequences after removing redundancy).
The specific methods and results of each of the stages of the MRC framework are presented separately, in sequence.
It all has to be in sequence.
However, the available evidence is inconclusive due to the existence of extended hiatuses and ambiguous chronological frameworks in most of the sedimentary sequences studied.
Their exceptional stability and tolerance to sequence substitutions has led to their use as frameworks in drug design.
The current study focuses on preparing a comprehensive litho-facies model in the framework of sequence stratigraphy.
In this framework, protein sequences in a genome can be viewed as modular because they are made up of combinations of structured and disordered regions.
In the cell assembly framework, the phonological sequences according to which speech sounds are lined up in words can be implemented by synfire chains parallel and precisely timed neuron chains contained in cell assemblies (Abeles 1991; Braitenberg and Pulvermüller 1992).
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