Sentence examples for framework sequence from inspiring English sources

However, the framework sequence of the HA in the pandemic 2009 IFV is radically different from that of seasonal H1N1 IFV, and thus inferences about a single point mutation amidst the sea of other changes is tenuous at best.

This implies that in these cases signature analysis supports the framework sequence based analysis.

For example CDR grafting [ 31, 32] makes use of germline antibody framework sequence as donor sequence for primary antibody construction.

As determining the interposal direction corresponding to the framework sequence was difficult, we could not construct consensus maps for these two chromosomes.

Further modification of the heavy chain framework sequence based on alignment to a larger number of canine cDNA sequences resulted in the modified heavy chain sequence "caN2-HCA1".

Our own antibody humanization efforts revealed that despite the high T20 scores for most donor human germline framework sequences, re-introducing specific parental framework sequences into a human germline sequence is sometimes sufficient to revert the T20 score of the humanized framework sequence to the same score as the initial parental framework sequence (Additional file 6: Figure S6).

It was directed by Rob Bowman and the framework sequences were filmed over the course of three days.

The framework sequences between CDRs can be similar or identical.

Hypervariable genetic cassettes encoding the complementarity-determining regions were introduced into the framework sequences to create >1.2×1010 clones.

The framework sequences of X72, X76, and X78 are shown in Figure 4. Phylogenic analysis indicates that these VH frameworks are undistinguishable from human germline families.

Apart from the microantibodies that may display anti-viral [25] and antitumor [26] activities as does the native Ab, less is known about the biological activities of other CDR and framework sequences tested as isolated peptides.