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This research is grounded in insights from a framework of responsible innovation [36], [52] which has been put forward to develop a shared understanding of how to bring societal and value questions to bear on research and innovation.
Outcomes of these questionnaires (also called client-related indicators) together with clinical indicators (e.g. incidence of skin ulcers, falls, malnutrition, and medication errors) form the national Quality Framework of Responsible Care [ 10].
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We need to do more across the board to understand trauma and create positive frameworks of responsible, positive action following negative events.
The elaboration of the Framework for Responsible Sharing of Genomic and Health-Related Data serves as an illustration of this process.
The development of the Framework for Responsible Sharing of Genomic and Health-Related Data [ 2] also serves as a current case-in-point.
The chemical industry has been experimenting with citizen advisory committees for a long time in the framework of its responsible care program (Lynne and Kartez 1995).
These developments inspired the adoption of a human rights approach manifest in the Framework for Responsible Sharing of Genomic and Health-Related Data (Framework) [ 4] of the Global Alliance for Genomics & Health (GA4GH) [ 5].
The Global Alliance for Genomics and Health has therefore adopted Data Safe Havens as a specific focus for its Regulatory and Ethics Working Group and this current paper reflects some of the key thinking arising from that decision, particularly through its foundational Framework for Responsible Sharing of Genomic and Health-Related Data (Global Alliance for Genomics and Health, 2014).
In the same line, the Global Alliance for Genomics and Health has adopted a Framework for Responsible Sharing of Genomic and Health-Related Data to support an international agenda for data sharing (Knoppers, 2014).
I223 is recognized as one of the framework residues responsible for stabilizing the NAI active site; type-specific mutations at these residues have resulted in reduced susceptibility to NAIs (11, 12 ).
Here we have restricted our analysis to the portion of the framework responsible for extracting and sieving through a set of precursor candidates originating from a genome-wide search.
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