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Very briefly, the initial stage of ossification involves synthesis and extracellular assembly of the collagen matrix framework of fibrils.
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Collagen based tissues present, at decreasing length scales, a complex framework of fibres, fibrils, tropocollagen molecules and amino-acids.
Using general kinetic results of nucleation theory, we analyze the polymerization of protein into linear or helical fibrils in the framework of the Oosawa-Kasai (OK) model.
In addition to these reports, Wu and colleagues and Blaschke and colleagues suggested that type-IX collagen may be an important stabilizing factor for cartilage type-II collagen fibrils, since it determines the resistance of the fibrils to swelling in the framework of cartilage [ 25, 26].
Within the ECM, such swelling is resisted by the collagen fibrils that form the framework of the cartilage.
Some of the diseases also feature clumps of fibrils called amyloids.
In each instance, the researchers said, the body eventually turns the protofibrils into sheets of fibrils called amyloid.
A different stain revealed what Alzheimer called "a tangled bundle of fibrils" — weedy, menacing strands of rope bundled densely together.
For determining the concentration of fibrils, the fibril reaction mix was centrifuged at 15,000×g for 15 min to separate the fibrils from the monomer.
The films composed of fibrils with a relatively broad size distribution delaminate more chaotically than the films composed of homogeneous fibril sizes.
Thioflavine T (ThT) assays were performed to quantify the amount of fibrils in suspension, observing a fluorescence signal proportional to the amount of formed fibrils [19].
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