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The variety of risk estimates in the various studies may reflect differing time frames of exposure measurement, different compositions of PM, different characteristics of the exposed populations, and considerable statistical uncertainties.
The CV substudy of the Detroit Exposure Aerosol Research Study DEARSS) was designed to elucidate the air pollution components and time frames of exposure responsible for affecting several CV outcomes, including arterial hemodynamics [i.e., BP and heart rate (HR)] and vascular function.
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"The metaphors are specific but given a life of their own somewhere off to the side, like a building just outside the frame of exposure which casts its shadow through a photograph.
Another study explored the time frame of exposure to hyperoxemia after cardiac arrest [ 93].
The time-frame of exposure assessment and the reliability of intake measurements are examples of methodological factors.
The main limitation of our study is that the questionnaire did not specify the time frame of exposure.
Several reports based on TST conversion indicate that the risk of being infected may be high, even within a limited time frame of exposure [ 23, 24].
If APC truncation mutations are involved in the initiating process, this association may be lost or diminished when using a parameter without time frame of exposure.
Further research is needed to determine the time frame of exposure represented by pesticide levels in meconium and to evaluate the dose-response relationship.
Therefore, we recommend that a follow-up study with more precise information about the time frame of exposure, a larger sample size, and a detailed account of chemical constituents of the pesticides should be conducted to further explore this question.
In our study, ANDV infection was not diagnosed in the index case-patient until he had been ill for 31 days, which resulted in a wider time frame of exposure for health care personnel.
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