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Jane Bown's increased frailty towards the end of her lengthy career forced the photographer to relax a life-long prohibition on having anybody extraneous with her on a shoot so occasionally I would get the call to accompany her.
Little is known about the patients' needs, and how their needs evolve over time with increasing frailty towards the end of life.
To our knowledge, this is the first prospective, longitudinal qualitative study on the needs of elderly patients with advanced frailty towards the end of life in German family practice, which integrates the perspectives of patients, informal caregivers, family physicians and other health professionals.
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This increased susceptibility towards frailty for obese older adults was surprising as frailty is often considered a wasting disorder [ 12].
We expect our data to help with the prediction of impending decline towards frailty as well as with identifying protective factors counteracting such decline.
Of thick skins and thin excuses No one is better suited to nursing Jeremy through his long night of the soul than Alastair Campbell, the campaigner for increased sensitivity towards mental frailty who – cross his heart – never briefed no one nor nuffink nor not about Gordon Brown's "psychological flaws" and Mandy being doolally.
We believe that the present study is an important step towards identifying frailty and its association with the quality of death in a rapidly developing nation.
To our knowledge, SHARE-FI represents the first European research effort towards a common frailty language at the community level.
Regardless of how frailty is conceptualized and measured, vulnerability towards death has been explained by two biological mechanisms: allostatic load and sarcopenia.
Taken together, these data point towards a possible association of frailty with inflammation and endothelial dysfunction, both also common in patients with CKD.
Interventions for physical frailty stem from the idea that the causal pathway towards frailty is a negative spiral in which inflammation, neuroendocrine deregulation and sarcopenia play a role implying that interventions can be targeted at physical frailty independent of specific diseases [ 15].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com