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The level of SIRT 2 was also lower in frail compared with nonfrail reaching the level of statistical significance.
Controlling for individual characteristics, women were more likely to be frail compared to men (OR = 1.39, 95 % CI: 1.23 1.56).
Older people transition between frailty states, 8 and pre-frail individuals have more than twice the risk of becoming frail compared with non-frail people.
An adjusted multinomial logistic regression model was developed to determine adjusted odds ratios of frailty (pre-frail or frail compared to non-frail) and individual characteristics (listed above).
The MRC men, whose scores also increased with age, were less frail compared to the women (median scores -0.811 vs. 0.132).
Individuals who triggered the Institutional Risk CAP were much more likely to be frail compared to those who did not (OR = 9.19, 95 % CI: 7.47 11.31).
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Risks of one-year mortality and hospitalization were estimated for those categorized as frail or pre-frail (compared with non-frail).
The unadjusted risk of functional disability was greatest among frail, and to a lesser extent pre-frail compared to non-frail individuals.
Adjusted risks of one-year mortality, hospitalization and long-term care placement were estimated for those categorized as frail or pre-frail compared with non-frail (or at high/intermediate vs. low risk on CHESS).
It was observed that among those participants with four or five risk factors there was a higher proportion of frail and pre-frail compared with non-frail (Fisher's exact test: P=0.005; P=0.021).
All of the results across all domains showed the same trend, indicating more preferable scores for non-frail compared to frail older people, with intermediate scores for the pre-frail people.
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