Clear differences between the preFrail and Frail classes became evident not earlier than after four years.
We further observed that the estimated probabilities of low physical activity exhibiting within latent frail classes were similar to those of two other objectively-measured components, regardless of whether subjects were stratified into two or three latent classes.
There were more deaths and refusals in the preFrail and Frail classes (Fisher p < .0005, p = .011), but no significant differences in losses to follow-up (Fisher p = .124).124
The increase of conditional probabilities of low physical activity from less-to-more frail classes within both the 2-class and 3-class models was similar to those of two other objectively-measured components: low grip strength and slow gait speed (data not shown).> -wrap-foot> Notes: AIC = Akaike Information Criterion; BIC = Bayesian Information Criterion.
In males, relative to the non-frail class, the unadjusted OR was 4.8 (3.7 - 6.2) in the pre-frail and 14.6 (10.3 - 20.7) in the frail.
In females, relative to the non-frail class, the unadjusted OR was 3.7 (2.5-5.3 2.5-5.3 pre-frain and 14.2 (9.7-20.8) in the frail.
Based on this, for females and males, we recalculated the unadjusted and age-adjusted odds ratios (ORs) for mortality at Wave 2 (with 95% confidence intervals, CIs) given the frailty class in Wave 1: In females, relative to the non-frail class, the unadjusted OR was 3.7 (2.7 - 5.0) in the pre-frail and 14.1 (10.4 - 19.2) in the frail.
Binary logistic regression was conducted to assess whether the DFactor classes at Wave 1 significantly predicted whether or not a subject was dead by Wave 2. In the model, the latent class membership variable was entered as a categorical predictor, using the non-frail class as reference category, and simple contrasts were requested.
The state only grew frailer.
Toward the end of the class, this big, frail man, who was confined to a high director's chair, said to the students, "Do you think there is such a thing as taste memory?" This set me thinking.
