It was considered that the greater flexibility of the polymer chains in the melt facilitated fragmentation of the chain and elimination of chain segments.
We have previously described a transgenic mouse overexpressing human heparanase, which results in extensive fragmentation of HS chains in vivo [ 11, 62].
Formation of a hyperbranched network structure through the fragmentation of side-chain reactive groups in the studied systems is confirmed by FTIR, TGA and DSC methods.
The result is a fragmentation of the chain into self-synchronized segments oscillating at different frequencies.
The mass spectra of these compounds are generally nonspecific due to the fragmentation of long hydrocarbon chains present in the compounds.
These alterations may reflect the loss of structural hierarchy through the unfolding of the protein molecules into a less ordered random coil form [8], [24], and fragmentation of the polypeptide chains [28], [29].
These data indicate extensive fragmentation of the alginate chains following heating at 200 °C.
"We've moved from relatively simple operations, where companies made things and sold them, to a fragmentation of the supply chain, where intellectual properties, intangible assets, are becoming more important," said Heather Self, a tax partner at law firm Pinsent Masons.
No fragmentation of the side chain was observed.
International fragmentation of the value chain does not occur exclusively in high-technology goods.
Our results demonstrate that peptide-induced depolymerization takes place via a heterogeneous, multi-step process that begins with internal fragmentation of the polymer chain.
