Fig. 1A (upper panel) demonstrates that the degree of chromatin fragmentation dose-dependently increases with an increasing oxidant:lipoprotein molar ratio.
The treatment of macrophage monolayers with MIP supernatant resulted into DNA fragmentation in a dose dependent fashion whereas chromatin condensation and nuclear fragmentation were also observed by DAPI staining at 6 hr of treatment (Fig. 1c, d).
In addition, ring fragmentation in low dose LatA treated clp1Δ cells can be rescued by mutations resulting in hyper-activation of the SIN.
Finally, manumycin 1 25 μ M for 24 72 h induced oligonucleosomal fragmentation in a dose- and time-dependent manner and MVA did not protect COLO320-DM cells from undergoing DNA cleavage.
Conversely, propidium iodide staining, PARP cleavage patterns, and random DNA fragmentation revealed a dose-dependent increase in necrosis in PARP+/+ but not PARP−/− cells.
As shown in Figure 3D, TCTP inhibited caspase-9, and -3 fragmentations in a dose- and a time-dependent manner.
NS-018 treatment increased both the percentage of annexin V-positive cells and the extent of DNA fragmentation in a dose-dependent manner.
Within the nucleus, nuclear envelope lamin B underwent covalent polymerization, which did not affect apoptotic nuclear fragmentation at low doses of DTHe.
While Android's continuing dominance in the mobile segment should not be a surprise to anyone, what may be more interesting is insight into how it will continue to be the leader for some time to come, with a heavy dose of fragmentation behind it ("others" are the second-largest category, with 660 million devices in 2014, more than iOS/Mac and Windows combined).
As shown in Figure 2B, dose-dependent fragmentation of DNA was observed with the production of a specific DNA fragment at all doses, in contrast with the DNA laddering induced by 1 µM etoposide.
The processing of caspases coincided with the demonstrated dose-dependent fragmentation of DNA.
