Due to an expanding knowledge about the molecular diversity the disease Osteogenesis imperfecta (OI), formerly known to be a disorder of the collagen synthesis, changed to a group of disorders with a fragile skeleton as common symptom.
There were sun-withered leaves and clods of moss in my hair and about 25 feet of pure, clear country air separating my fragile skeleton from the hard, unforgivable ground.
When the rate of bone resorption exceeds that of bone formation, destruction of bone tissue occurs, resulting in a fragile skeleton.
And until recently, most researchers hadn't been doing the kind of careful excavation necessary for discovering fragile fish skeletons.
Fragile larval skeletons may be the weak link for persistence of some species.
We focused on the larval stage because it produces a fragile calcite skeleton, and because this life stage has a planktonic period of days or weeks in the water column where seawater chemistry and temperature have a major impact on development.
Although wet silica gels and bacterial cellulose gels seriously crack and shrink, respectively, when they exist individually, synergic effects between the fragile silica gel skeleton and soft bacterial cellulose gel skeleton ensure structural integrity of the composite gels during ultrafast evaporative drying.
Maybe Blankie was holding the boy's love hostage; it was certainly capable of this, despite being as thin and as fragile as a leaf skeleton.
Then, she is a young transplant doctor talking to her own beloved Aunt Grace, who has been transformed by chronic renal failure into a living skeleton, too fragile to survive long on dialysis, too tiny for a kidney transplant.
No, you feel more like a helpless and overwhelmed mess of human flesh tenuously stuck to a skeleton, a fragile arrangement that might otherwise fall to pieces, were you not suffused with the extraordinary energy of boundless affection.
