Combining a heavy Nokia 1520 with fragile materials was problematic, and there were also issues with turning them on and maintaining battery life once attached to the skirt.
For mechanically fragile systems (such as proteins), this is problematic as in order to reach the same macro-mixing, much higher maximum shear rates are realized in the impeller zone.
Third, Merkel's decision rips the very engine out of the entire integration idea: that Germany, Europe's historically problematic core country, underwrites the ever-fragile idea of European politics transcending the merely national.
The album's boldest and most problematic moments are its symphonically weighted versions of two Mitchell originals, "A Case of You" (originally a fragile folk-pop lament sung against a quivering dulcimer) and her most famous song, "Both Sides Now".
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Since vitellogenin is so abundant in the yolk and the yolk sacs of endemic fish can be quite fragile, although the prospect of this methodology is enticing, having vitellogenin as a read out for proteinuria of developing embryos is problematic.
