"It's very important that papers like this are published so that we are reminded how fragile our knowledge of the universe is".
The hormone replacement story is a perfect case study in this domain; it has much to teach us about how fragile our knowledge base can be concerning a drug's ultimate effects.
Based on cytological observations and prior knowledge of fragile sites on human chromosomes, we conclude that the high frequency of chromosome lesions is the result of the expression of fragile sites in 45S rDNA.
Raised in Guyana, by training a surveyor with a profound, life-changing knowledge of the fragile eco-systems of his native land.
The intricate sexual obsessions that characterised Baker's novels Vox and The Fermata, have been replaced with a sense of fragile domestic perfection and a creeping knowledge of mortality.
Arguments to the contrary say that heterosexuality is not that fragile, and that children can handle knowledge and exposure to gays and lesbians.
Many low- and middle-income countries have health systems that are weak and fragile, lacking the capacity to put knowledge into practice and expand the delivery of health services to those in need [ 1].
Early childhood experts continually advocate for appropriate supports for young children in any fragile situation well founded on evidence-based knowledge on cognitive child development.
Poor people live haunted by the knowledge that decent housing is a fragile condition.
To our knowledge, three regulators of the Drosophila Fragile X protein had been previously reported [24], [43], [44].
