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In one trial examining the use of oral alendronate in institutionalized elderly, hip fractures were not significantly reduced; however the trial was not adequately powered to detect fracture outcome differences (n = 327) [327.
Most studies included fracture outcome data.
The results in Figure 2 describe the association of adherence and fracture outcome, and those in Figure 3 depict the association of persistence and fracture outcome.
We restricted our comparative analysis to the hip fracture outcome as this is directly comparable between both scores, whereas the FRAX fracture outcome also includes humerus fractures.
Our fracture outcome did not include fractures of the lumbar or thoracic spine by design.
Of particular interest for the fracture outcome, this included thiazolidinediones, mainly rosiglitazone.
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In a study underpowered for fracture outcomes, alendronate did not significantly reduce hip fractures in LTC.
We performed a scoping review of randomized controlled trials of interventions tested in the long-term care (LTC) setting, examining hip fracture outcomes.
A data abstraction form including study characteristics and fracture outcomes was utilized (sample data abstraction form available from the corresponding author upon request).
Information on hip fracture outcomes was a requirement for inclusion (reported either in the primary publication or obtained from the author through correspondence).
In this study, which was not powered to detect differences in fracture outcomes, the OR of hip fracture in the treatment group was calculated to be 0.50 (95% CI 0.09, 2.75).
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