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External beam radiotherapy to a total dose of 50 Gy was delivered in 2 Gy fractions per day, 5 days a week, by using an isocentric technique via a pair of parallel opposed anterior and posterior ports and 18-MV X-ray beam.
A randomised phase II trial was initiated to explore the feasibility of concomitant cisplatin and radiotherapy with conventional fractionation (CF) or multiple fractions per day (MFD) for patients with locally advanced head and neck malignancies.
This is achieved by delivering 2 or 3 fractions per day with normal-sized fractions.
A three fractions per day regimen was adopted with an interfraction interval of 6 h at least.
A dose of 12 15 Gy with 3 Gy single doses and 2 fractions per day (≥6 h between fractions) with D90% for the CTV/PTVBRT is applied.
There are two modalities of shortening overall time of radiotherapy without increasing late complications and allowing for better efficacy outcomes: first is two fractions per day, second is using fewer and larger doses [ 20, 21].
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Patients received one fraction per day, 5 days per week.
The total radiation dose was 50.4 Gy in 1.8 Gy per fraction per day, 5 days per week.
The total radiation dose was 50.4 Gray (Gy) in 1.8 Gy per fraction per day, 5 days per week.
The RT dose was calculated at the isocenter of the multiple fields and delivered at 180 cGy per fraction per day, five days a week, up to a total dose of 4,500 cGy in five weeks.
Patients with SD (no change in scope of surgery) and patients with PD (increase in scope of surgery) were assigned to neoadjuvant RT at dosage of 50Gy (2Gy fraction per day, 5 days per week for 5 successive weeks), given until completion, patient refusal, or unacceptable RT-related toxicities.
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