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Conventional fractionation (single dose 1.8-2 Gy) was used in all cases.
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The fractionation schemes included single doses and 2-64 frandions, and the overall times ranged from 1 day to 6 months.
Previous studies have employed a single dose of 5 20 Gy radiation, but typical clinical fractionation schedules involve treatment with 1.5 2 Gy per day to a final 60 100 Gy exposure.
Considering the increased biological effectiveness of a high single dose [ 26], total doses which are equivalent to 60-70 Gy in conventional fractionation can be achieved using an IORT boost in combination with moderate doses of external beam radiation therapy [ 27].
Exposure to gamma-irradiation at a single dose of 10 Gy resulted in increased numbers of centrosomes with varied abnormalities and cell fractionation (reviewed in Sato et al. 2004).
Seventy-six millioneedildren need single dose treatment.
A pouch amounts to a single dose.
A single dose costs $2000.
RIPC: Remote Ischemic Preconditioning, SD: Single Dose, MD: Multiple Dose.
A single dose was lethal.
This implies that increasing the fractionation for slow growing tumors or nonneoplastic lesion may not bring a biological better response of the tumor if compared to a single dose if we accept a low α/ β ratio for benign or slow growing tumors according to the most recent clinical data.
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