Sentence examples for fractionated dosing from inspiring English sources
Fractionated dosing causes a greater degree of DNA damage, which may suggest a greater degree of efficacy, with a good correlation between pharmacokinetic and pharmacodynamic data.
The COMETs and accompanying histograms clearly show the evolution of DNA damage from pretreatment levels to the maximum degree of DNA damage 72 h after the start of administration, for both 72-h infusion and fractionated dosing over 3 days.
The total AUC of the parent drug was not different in those patients having fractionated dosing over 3 days compared to those receiving a continuous infusion and there was no difference in the AUCs of the metabolites comparing the two groups.
Recent clinical data in patients with advanced pancreatic cancer suggest a fractionated dosing regimen using a Y-labelled antibody given in combination with low-dose (radiosensitising) gemcitabine can provide disease control and even objective responses (Ocean et al, 2012), giving credibility to pursuing Y instead of Lu for patients with advanced metastatic disease.
This study was designed to determine if the addition of NS-398 to NPe6-induced PDT in single or fractionated dosing would result in greater tumor kill.
A lower AUCHD (mean 1190) was observed following 2 days of fractionated dosing.
This is the first report of experiments performed after radiation delivery using high fractionated doses approximating usual treatment of SCC in human.
This study was designed to assess the efficacy and outcomes of argon plasma coagulation (APC) in the management of chronic radiation proctitis after conventionally fractionated, dose-escalated radiation therapy (≥7560 cGy).
Two paediatric patients were prescribed fractionated doses of 9 and 8.5 Gy, respectively.
Mortality in animals with Tumour 3924A increased from 10% following one large single dose to 60% for animals given daily fractionated doses for 3 days, and 80% for animals given daily fractionated doses for 5 days.
As shown in Figure 6, fractionated doses of RT slightly delayed the tumor growth when compared to the untreated tumors.
