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Dose fractionated data (3 5 frames per projection image) were collected using Digital Micrograph (Gatan, Pleasanton, USA) at a nominal magnification of 34,000× (corresponding to a pixel size of 0.66 nm) in the Polara or at 33,000× (corresponding to a pixel size of 0.42 nm) in the Krios.
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The dose was based on previous experiments, indicating that 12 Gy single fraction has equivalent tumour growth inhibitory effect as 4 Gy × 5 fractionated irradiation (data not shown).
Both these combined fractionated treatment data suggest no inhibitory effect on repair of sublethal radiation damage.
The difference between treatment schedules was statistically significant (P=0.0035, one-way ANOVA), if the fractionated dosing data are restricted to those patients who received 9g m−2, the same dose as the continuous infusion patients.
Bitumen is fractionated experimentally and the measured data for each fraction is used to tune the EoS.
Gradients were fractionated with fraction collector Model 2128 (Biorad).
The polymers were fractionated by fractional precipitation.
These results echo recent data in which fractionated IR led to a relative increase in the fraction of senescent cells in vitro in breast cancer non-TICs versus TICs [ 12].
An Italian phase I-II trial [ 24] treated 50 patients with helical IMRT using 58 Gy in 2.8 Gy fractions with excellent safety outcomes that were comparable to their data on conventionally fractionated treatment.
Hypo-fractionated image guided radiosurgery significantly improves pain relief compared to historic data of conventionally fractionated radiotherapy.
It is the study hypothesis that hypo-fractionated image-guided radiosurgery significantly improves pain relief compared to historic data of conventionally fractionated radiotherapy.
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