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Images from breast magnetic resonance imaging (MRI) are another way to determine the fraction of tissue in different quadrants.
These methods will only capture the fraction of tissue with the highest uptake and exclude the low uptake areas.
However, assuming uniform perfusion, the fraction of microvessels in the UOQ should be proportional to the fraction of tissue in that quadrant.
11C-PK11195 uptake was quantified using the Standardized Uptake Value (SUV), corrected for the fraction of tissue in each lung region (as assessed in CT).
We made estimates of the fraction of tissue in each of the 4 quadrants and in the nipple/areolar/central region because this has not been previously measured.
While there has been some success in predicting the breadth of expression (i.e., the fraction of tissue types a gene is expressed in), predicting tissue specificity remains challenging.
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However, if tissue-maintaining cells constitute only a subpopulation of these basal progenitors, we would obtain the same long-term clone fate behaviour, Equation 1, while the overall fraction of tissue-maintaining cells, ρ, would have to be adjusted accordingly.
We observed that an underappreciated, large fraction of tissue-specific genes 64% of heart genes, 47% of brain genes, and 50% of lung genes lack proximal enhancers and are being regulated by so-called tele-enhancers (enhancers that are separated from their target genes by at least one bystander gene or exon).
To consider the driving factors for clustering, it is highly informative to check the fraction of tissue-specific genes in clusters formed by gene duplication events, since gene duplication will overwhelmingly produce new gene copies in very close proximity to the original gene locus which are likely to retain their tissue specificity unless they evolve new functions.
In Table 6, we summarize the fraction of tissue-specific genes clustering in each tissue whereby we recognized two genes expressed in a given tissue as belonging to a single cluster if they were within 100 kb on the same chromosome.
Western blot analysis of these protein fractions revealed the presence of γ-synuclein in the detergent-insoluble fraction of tissues dissected from the dorsolateral column, but not from the anterior horn areas (Fig. 3).
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