While Obama attended four times the number of fund-raising events that Bill Clinton did during his first year in office, he garnered a fraction of the contributions.
And in 2004, New Jersey Democrats gave to charity a fraction of the contributions they had received from real estate developer Charles Kushner, who had donated money in the names of his partnerships without authorization.
As has been commented by many authors [4], [5], [6], these small effects mean that the current discoveries explain only a small fraction of the genetic contribution to the disease.
A great majority of genetic markers discovered in recent genome-wide association studies have small effect sizes, and they explain only a small fraction of the genetic contribution to the diseases.
Most variants identified have disappointingly small effect sizes, and thus explain only a fraction of the genetic contribution to a particular trait or disease [ 57].
The fraction of each contribution to the total grain processing of (i), (ii), and (iii) (i.e., the relative importance of the three contributions to all grain processing mechanisms) is 30 50%, 20 40%, and 10 40%, respectively.
But they remain a small fraction of the total human contribution to the atmosphere's natural heat-holding greenhouse effect, which is cumulative because of the long-lived nature of carbon dioxide and some other heat-trapping gases.
Remanence carriers may only comprise a small fraction of the total magnetic contribution and the proclivity of each fraction to alter may differ.
Compared to the known heritability of type-2 diabetes, which is around 40% [7], this means we have discovered only a small fraction of the potential genetic contribution to the disease.
Cumulatively, eGFR-associated loci explain only a small fraction of the total heritable contribution eGFR and stratifying by albuminuria status in our existing genome-wide association study datasets 3– 5 can help us to uncover the missing heritability.
