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(B) A contour plot shows the fraction of simulations won by PCD+ as a function of disaster probability and migration.
The contours show the fraction of simulations whose lightcurves yielded P < 0.01, or equivalently log10 P-1) > 2, for the given test.
Panels show the fraction of simulations exhibiting emergence consistent with warming by the year 2000 in 'HistoricalNat' simulations (a,b), 'Historical' simulations (c,d) and 'HistoricalGHG' simulations (e,f) of TN90p (left panels) and TX90p (right panels).
Panels show the fraction of simulations exhibiting emergence consistent with warming by the year 2000 in an ensemble of 540 85-year time series of TN90p (a) and TX90p (b) drawn from the bias-corrected 'piControl' simulations in terms of a block-bootstrap approach to mimic the length of the 1921 2005 historical period (see Methods).
Empirical p-values were calculated as the fraction of simulations that produced a number of mapped features as extreme as observed in the real data [56].
Fig 6a illustrates reprogramming efficiency (the fraction of simulations which resulted in a noise-driven transition to the pluripotent state) in the presence of noise in the expression of the PGs only (blue); and in the presence of noise in the expression of OCT4 and SOX2 only (red).
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Results were expressed as the fraction of simulation time the atoms were within hydrogen bonding distance.
For a fixed positive feedback strength, they found that 1,000 molecules yields the maximum probability (fraction of simulation runs) for polarisation.
Figure 6 displays the success rate (i.e., the fraction of successful simulations).
P-values of events were estimated by the fraction of random simulations supporting the null hypothesis.
The rates of phosphorylation and dephosphorylation (k7 and k13) were varied only over two orders of magnitude because a large fraction of the simulations failed when these rate constants were varied over a wider range.
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Justyna Jupowicz-Kozak
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