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The total number of positive hybridisation signals was 70,667 probes, indicating a large fraction of mismatch hybridisation.
Therefore, these reports suggested that the FHIT gene might be a target of damage in a fraction of mismatch deficient tumours.
Recently, it has been reported that the Fragile Histidine Triad gene may be a target of damage in a fraction of mismatch deficient tumours.
Recently, Fong et al (2000) have demonstrated that NMBA (N-nitrosomethylbenzylamine) exposure caused a spectrum of visceral and skin tumours similar to Muir-Torre syndrome, caused by a deficiency in a MMR gene, in Fhit-deficient mice, and suggested that the FHIT gene may be a target of damage in a fraction of mismatch deficient tumours.
Similar(56)
Moreover, it has been shown that RecA protein does not significantly discriminate between perfect and imperfect matches of sequence until the fraction of mismatches approaches 10% [51].
The fraction of mismatched read pairs at each base dramatically decreased with increasing Q-score.
Roughly speaking each divergence corresponds to fraction of mismatches in the reads after accounting for sequencing error.
The gap-free part of the alignment with the best hit was used for SNP identification, if the fraction of mismatches did not exceed 5%.
The fractions of mismatching nucleotides were subsequently calculated.
contains a significant fraction of the mismatch probes: typically 35%.
A large fraction of hetero/homoplasmic mismatches (more than 50%and76%6%, respectively) was also found in patients.
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