Sentence examples for fraction of dose from inspiring English sources

In contrast, high fraction of dose absorbed (Fabs) was reported for codeine, which challenges the generally recognized Peff Fabs correlation.

The target was to achieve a naproxen apparent permeability (Papp) value close to that previously obtained using a Caco-2 cell dynamic methodology (4.88 × 10−5 cm s−1), which related well to the fraction of dose absorbed in vivo in human.

This is important for considering the fraction of dose absorbed and the specific activity ratio of serum/liver.

The fraction of dose excreted (%Fe) was 4.0 6.3% in Japan and 4.0 4.4% in the UK.

The impact of cotreatment with ketoconazole observed by Samer et al. was used to refine the fraction of dose of the drug metabolized by CYP3A4 (fm-3A4).

The fraction of dose absorbed (Fa) was predicted to be dose-dependent and would decrease from 1 to 0.42 over the dose range of 5 240 mg, suggesting the absorption of BMS-911543 is a saturable process.

Condition 2. The number of doses where criterion 1 is true meets a defined fraction of doses over the 140 treatment doses.

The patterns of adherence – particularly, whether reversion can occur within the intervals of non-adherence – can therefore influence the overall exposure to drug resistance even for the same total fraction of doses missed.

For a fixed fraction of doses taken, this depends on the duration of adherent and non-adherent spans another variable is the degree of periodicity or stochasticity in these durations.

Fractions of dose that escape hepatic (Fh) and intestinal (Fg) first-pass metabolism were estimated based on the well-stirred model and the Qgut model, respectively, using CLint obtained as described and CYP3A content values reported by von Richter.

It is to be noted that, in our estimation of the absorbed dose, the fraction of the dose recovered in urine as metabolites was not considered in dose reconstruction.