The effects by the water-soluble fraction would be more biologically relevant because components in this fraction are more likely than the whole particles or the insoluble fraction to gain access to the pulmonary vessels quickly by diffusion after the particles are inhaled into the lung.
Instead, the antimutagenic potency of the BBI fraction is more likely linked to modulation of DNA at the transcriptional level.
Cells isolated from the SP fraction were more likely to survive and form viable colonies at the end of 3 weeks.
Notably, randomized studies using bone-marrow derived cells for treatment of acute myocardial infarction suggested that patients with larger infarcts and/or lower ejection fraction are more likely to benefit from cell therapy [ 16, 22, 29].
Patients exposed to inotropes differed from those unexposed in that they were older; had higher Parsonnet scores, more comorbid illnesses and lower preoperative left ventricular ejection fractions; were more likely to have undergone valvular or combined procedures; and had longer bypass times.
Considering cell proliferation in embryogenesis, an pSNM with relatively higher mutant allele fraction might be more likely generated by postzygotic mutations at the early developmental stage and, therefore, be more likely shared between somatic and germ cells.
In particular, we contend that hyperoxia implies the administration of high FiO2 fractions, making it more likely for hyperoxia to actually be a marker of illness severity than a biological toxin.
Our hypothesis in this study was that the ultrafine fraction of PM, which more likely would have direct contact with pulmonary vasculature when inhaled than fine and course PM, is capable of inducing transcriptional changes indicative of endothelial cell dysfunction.
Dust samples were then manually sieved to obtain the fine fraction (<150 μm), which is more likely to adhere to human skin [ 15].
