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Our study compares two techniques using the same fractionation scheme, with a fraction dose of 2.66 Gy and a total dose of 42.65 Gy.
The optimal volume of irradiation, total dose, fraction dose, techniques of radiotherapy, and the end points used during the follow-up are open to debate.
Treatment techniques using a pair of tangential wedged fields (TWFs) and 4-field intensity-modulated radiation therapy (IMRT) were designed with a prescribed fraction dose (Dp) of 180 cGy.
The average fraction dose was 7 Gy.
But a higher fraction dose could increase the risk of late skin or breast toxicity [ 22].
Furthermore 2 Gy is the standard single fraction dose in our clinical setting.
Similar(33)
To date, radiosurgical treatment has achieved widespread success based on careful joint patient selection, optimal treatment planning, and accurate dose delivery based on direct participation by a trained and responsible neurosurgeon working closely in conjunction with a radiation oncologist well versed in the single fraction dosing of radiation.
Doses were delivered in five fractions per week, and fraction doses ranged from 1.8 to 2 Gy.
In 4 patients, the total dose was applied in a hyperfractionated regimen using single fraction doses of 1,6 Gy.
Radiotherapy was administered locally with one dose of 8 Gy or two weekly fraction doses of 8 and 7 Gy, respectively, for a total dose of 15 Gy.
Optimal treatment implies application of state-of-the-art resective surgical and RT techniques [26], avoiding excessively high fraction doses [29].
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