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When number of observations per dose was increased to four, specificity increased up to 98%%.
Thus due to the fact that MFMS is a minimum of the four specificity indicators (1.1), the bounds for CPI and CS show only linear increase with CRT.
This is due to the fact that MFMS is a minimum of the four specificity indicators, (1.2), and thus is constrained by the smallest one.
While 15 of the mutants showed the same ΔΔ Go values for the two aa-tRNAs, there were four "specificity" amino acids where the ΔΔ Go values differed between the two tRNAs.
In that study, we used carboxymethylcellulose as a model water-soluble polymer and cyclic peptide 1 a potent synthetic QSI that can inhibit the agr-type QS circuits in all four specificity groups of S. aureus at subnanomolar levels to design thin polymer coatings that can release or "dump" QSI into surrounding media rapidly on exposure to aqueous environments (e.g., over several minutes).
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In addition, four specificity-determining positions were predicted to be responsible for functional specificity.
Four additional patient sera displayed four specificities.
One might speculate that the same differences in the recognition domains of the two sigma factors may also account for the discrimination of Rsd to engage specifically with one of the two specificity factors.
In view of this finding, the original classification of caspases into three specificity groups needs to be modified, at least for caspase-8, which tolerates small hydrophobic residues as well as the acidic residue Asp in subsite S4.
Type I DNA methyltransferases contain one specificity subunit (HsdS) and two modification subunits (HsdM).
The possibility that isolated CDRs, represented by short synthetic peptides, may display antimicrobial, antiviral and antitumor activities irrespective of Ab specificity for a given antigen is addressed here.
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