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In PanNET four major pathways are affected by genetic and epigenetic alterations: chromatin modification and telomere maintenance, DNA damage, mTOR signalling and hypoxia.
There are essentially four major pathways of E2 metabolism in estrogen-sensitive tissues (Fig. 1).
Metastases develop through four major pathways: direct extension, intraperitoneal seeding, lymphatic and haematogenous spread.
Hyperglycemia-induced mitochondrial overproduction of reactive oxygen species (ROS) activates four major pathways of diabetic cellular damage.
Metastases develop through four major pathways: direct extension, intraperitoneal seeding, lymphatic spread, and haematogenous metastases (Fig. 5) [ 14].
Below, we discuss the involvement of four major pathways (IGF1-Akt-FoxO, myostatin, NFκB and glucocorticoids) in muscle atrophy.
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Two major pathways of MSNs are known.
There are six major pathways using HR, also referred to as HR sub-pathways [18].
Two major pathways regulating the immune response are the JAK/STAT and MAPK/ERK pathways.
First, regarding the transformation of disputes, the aforementioned "process model" and "meaning model" represent two major pathways within existing studies.
In living cells, the endocytosis involves three major pathways, including caveolae-mediated endocytosis, macropinocytosis, and clathrin-mediated endocytosis.
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