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Internally, we call our founder analysis FQ or the Founder Quotient.
The starlike pattern enhances the precision of the dating of the human entry into the Americas, but inevitably hinges upon the calibration employed and, perhaps more importantly, on a detailed founder analysis across the double-continent.
A preliminary founder analysis indicates that the settlement of El Salvador occurred about 13,400±5,200 Y.B.P.The founder age of A2 in El Salvador is close to the overall age of A2 in America, which suggests that the colonization of this region occurred within a few thousand years of the initial expansion into the Americas.
Routine genotyping of all the newborn (F1 and F2 generations mice) was performed by PCR with one of the primer sets used in the founder analysis.
The founder analysis of the mtDNAs in this study suggests 50.0 ± 1.5 kyBP for such arrival which is well within the lower bound range of earlier estimates and perhaps more consistent with the earliest and most pronounced population expansion in southern Asia around 52 kyBP suggested in [ 28].
For example, a regionally-specific clade may have arisen from a migration event on the edge in the tree leading to that clade, and if the diversification has then arisen in situ rather than prior to the presumed founder event, the estimate of the time to the most recent common ancestor (TMRCA) can provide a minimum bound on the age of the migration event (motivating the "founder analysis" [ 24]).
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Age 51 Education L'Institut de l'Assomption, Paris; Yale University BAA, History); London Business School (MBA) Career 1981 Alan Patricof Associates/Apax Partners 1984 Head of business development, Virgin Group 1986 Head of marketing, Superchannel 1989 Director of corporate entertainment, TVS Entertainment 1992 Corporate development manager, Thorn EMI 1997 Founder, Enders analysis.
Archived tissue blocks were used as the source of DNA for Ashkenazi Jewish BRCA1/ BRCA2 founder mutation analysis.
Unlike mutation screening of cancer genes, founder mutation analysis will not identify DNA variants of uncertain clinical significance.
Identification of high-risk families through founder mutation analysis of BRCA1 ensures that families with maximum risks are given first access to the limited resources of the high-risk clinics.
Individuals ("samples") were chosen, within each province, based on two different strategies, the "grandparents criterion" and "founder surnames analysis", so that were included into the study only those individuals whose four grandparents were born in the same sampling area, taking also into account the presence of founder surnames.
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