Taking a longer view, the hand-in-hand development and testing of computational approaches, as outlined above (see 'Synergy between experimental and computational enzymology'), will ultimately provide foundational models for the efficient design of highly effective and specific new enzymes.
We used CREATE as the foundational model for selecting quantitative outcome measures and qualitative interview questions to evaluate the PEAK program.
This betwixtness of socio-technical design is demonstrated by the analysis of two IT systems for health care: a foundational model for electronic health care records, and an IT system organizing hospital porters' work.
Drosophila melanogaster is the foundational model organism for investigating circadian rhythms.
Examples are Pisanelli (1998) and Schulz (2001) for the UMLS; Beck (2003), Dameron (2005) and Golbreich (2006) for the Foundational Model of Anatomy; Wroe (2003) and Egana (2008) for the GO and Heja (2007) for ICD-10.
The objective is to represent the Foundational Model of Anatomy (FMA) in the OWL 2 Web Ontology Language (informally OWL 2), and to use it in a European cross-lingual portal of health terminologies for indexing and searching Web resources.
The Foundational Model of Anatomy (FMA) is the reference ontology regarding human anatomy.
The fly genus Drosophila (Diptera: Drosophilidae) has served as the foundational model system in animal genetics for more than a century (Morgan 1910; Sturtevant 1913) and has been the source of crucial insights into many biological processes.
For example, the components and parts of organisms are described in anatomy ontologies such as the Foundational Model of Anatomy (FMA; Rosse and Mejino, 2003) or the cellular component branch of the Gene Ontology (GO; Ashburner et al., 2000).
Similarly, the Foundational Model of Anatomy alone is not suitable for detecting potential targets of nanoparticles, since in addition to anatomical locations, potential targets of nanoparticles may also include animals and the environment.
