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Phosphorylation of Ser831 and Ser845 sites of GluR1 is essential for the trafficking and function of AMPAR, which is the foundation of synaptic plasticity and learning and memory (Hu et al., 2007).
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"It's consistent with comparative genomics research indicating that the molecular basis of synaptic plasticity was modified in human evolution," he says.
Myelination: An Overlooked Mechanism of Synaptic Plasticity?
LTP is a form of synaptic plasticity, in which connections between neurons are strengthened.
Regulation of synaptic plasticity genes during consolidation of fear conditioning.
Fields, R. D. Myelination: an overlooked mechanism of synaptic plasticity?
Abraham, W. C. & Bear ,M. F. Metaplasticity: the plasticity of synaptic plasticity.
Regulation of synaptic plasticity in a schizophrenia model.
Thus, synaptic signaling of RA may mediate multi-faceted regulation of synaptic plasticity.
Importantly, few studies have directly addressed the source of ROS in the context of synaptic plasticity.
In addition, autophagy has been recently implicated in the regulation of synaptic plasticity.
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