Interestingly, SREBP1 was found to regulate the transcription of the androgen receptor (AR) gene (Huang et al., 2010), and to promote proliferation, migration and invasion in prostate cancer (Huang et al., 2012).
The RANKL/RANK signaling axis has also been found to regulate cell migration in human chondrosarcoma cells, through MEK, ERK, IKK α/ β, and NF- κB signaling and upregulation of β1 integrin [ 56] (Table 1).
Also, JWA was found to regulate cancer cells migration via MAPK cascades and suppress the ability of adhesion, invasion and metastasis by integrin alphaVbeta3 signaling [ 11, 12].
The EGFR signaling pathway has been found to regulate apoptosis, cell cycle progression, proliferation, differentiation, migration, and other biological processes.
These results suggest that LEF-1 could regulate the migration of colon cells through CXCR4.
Further, this pathway also appears to regulate the directional migration of these cells [ 107].
Importantly, 1,25(OH)2D3 regulates the migration of TH17 cells into the CNS by suppressing CCR6 expression.
Fingolimod also regulates the migration of B cells and dendritic cells, and enhances endothelial barrier function.
It regulates the migration of keratinocytes and fibroblasts in culture, and wound healing in vivo [85].
The CCL gene family encodes chemokines, small proteins regulating the migration of lymphocytes.
