MMP-7, in turn, was found to regulate the angiogenic activity of fibroblasts [ 38].
Additional factors with biochemical and/or genetic links to SIN3 activity have also been found to regulate the length of the adult lifespan.
Moreover, tetraspanin 12 was found recently to regulate the activity of membrane metalloproteinases, MT1-MMP/MMP14 [ 46] and ADAM10 (disintegrin and metalloproteinase domain-containing protein 10) [ 47].
Furthermore, signaling kinases were found to stably associate with promoters as well as gene body regions to regulate the activity of those elements [37 39].
One encoded a DON-Glucosyltransferase termed UGT73C5, which was found to regulate BR activity by catalyzing the 23-O-glucosylation of BL and castasterone.
The phosphorylation of SIN1 by Akt was found to regulate mTORC2 activity in response to growth factors, revealing topological insights into the Akt/mTOR signaling network.
As the processome was found to regulate its own activity [ 17], reduction of its abundance may lead to decrease of its own transcription.
TAK1 is found in complex with binding partners TAB1 3, phosphorylation and ubiquitination of which has been found to regulate TAK1 activity.
Similarly, ERK was also found to directly regulate the activity of pRB1).
