Conversely, H19 has been found to regulate the rate of tumor metastasis in advanced stages of HCC via the epigenetic activation of the miR-200 family [ 79].
In this regard, it has been previously found that gangliosides inhibit tyrosine phosphorylation [35], particularly GD3, which has been shown to regulate the activation of Lyn, a member of the Src family, by their interaction in caveolae-like domains [36].
Moreover, Src kinase has been found to regulate activation of Akt, FAK1 and ERK in human cancers including breast cancer (Reynolds et al, 2013; Zhang et al, 2013).
The MEK/ERK pathway was found to regulate transcription of the MAF proto-oncogene through ERK activation of FOS, a finding consistent with MAF protein and mRNA levels being downregulated following MEK inhibition.
Serpins comprise a superfamily of genes that were originally found to regulate physiologic functions such as blood clotting, complement activation, programmed cell death, and inflammatory processes [2].
Comparing our findings to previous reports examining the role of individual PKC isoforms in ADAM protease activation, PKCα was found to regulate both basal and PMA-induced N-cadherin cleavage by ADAM10 [32].
Therefore, we designed experiments to determine the roles of Cab45S in cancer cell apoptosis and found that Cab45S regulates the activation of the IRE-JNK signal pathway via GRP78/BiP, and has an important role in inhibiting ER stress-induced apoptosis.
We found that SFAs had a more profound effect on Atr phosphorylation and activation of Chk1, implying that SFAs might mainly regulate the activation of Atr and/or the phosphorylation of Atr targets.
TAK1-binding protein, TAB1, can specifically regulate the activation of TAK1.
Recently reported miRNAs can regulate the activation of HSCs and thereby regulate liver fibrosis.
Therefore, FADD could transcriptionally regulate the activation of signaling pathways.
