IL-23 was also found to potentiate the effect of IL-21/TGF-β co-treatment as IL-21 upregulated the expression of IL-23R, RORγ and Th17 cytokines and inhibited the expression of TGF-β and FoxP3 [75].
It was subsequently found to potentiate the functions of Ras in some cells and to antagonize them in others [28].
Cetuximab has been found to potentiate the effects of radiotherapy in experimental systems [ 13- 15].
Cetuximab has been found to potentiate the effects of chemotherapy and radiotherapy in experimental systems [ 8- 10].
Tamoxifen was found to potentiate the effect of atRA to inhibit estrogen-induced growth of MCF7 cells [ 31].
Quite significantly, a purified inhibitor of IDE (of undetermined identity) was found to potentiate the hypoglycemic action of insulin in vivo as early as 1955 [15].
ABT-737, which targets BCL-2, BCL-XL, and BCL-W [ 66], was found to potentiate the response to docetaxel in PDX models of triple-negative breast cancer [ 35], suggesting that elevated BCL-2 expression in this subtype constitutes a predictive marker.
This suggested a possibility to use cold-inducible plant transcription factor as a tool to potentiate the expression of transgenes under the control of cold regulated promoters.
Speculatively, β-catenin may interact with N2ICD to potentiate the expression of Notch-2, but more studies are needed to outline this interaction.
Indeed, ectopic expression of Smac was found to potentiate transcription of endogenous NF-κB-responsive genes.
