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Cetuximab has been found to potentiate the effects of radiotherapy in experimental systems [ 13- 15].
In preclinical studies, veliparib was shown to be a potent inhibitor of PARP and was found to potentiate the effects of TMZ, platinum agents, cyclophosphamide, and radiation in syngeneic and xenograft tumor models.
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IL-23 was also found to potentiate the effect of IL-21/TGF-β co-treatment as IL-21 upregulated the expression of IL-23R, RORγ and Th17 cytokines and inhibited the expression of TGF-β and FoxP3 [75].
Ozone was also found to potentiate the methemoglobinemic effects of nitrogen dioxide, particularly in sequential studies in which ozone exposure preceded nitrogen dioxide.
An anti-betacellulin antibody (which blocks the effects of betacellulin) in combination with Iressa was found to potentiate the inhibitory effect of Iressa in cell viability experiments (Figure 3D).
Resveratrol has also been found to potentiate the efficacy of chemotherapeutic agents and minimize the side effects associated with them [ 20– 20].
Cetuximab has been found to potentiate the effects of chemotherapy and radiotherapy in experimental systems [ 8- 10].
This suggests that the low genistein dose is able to potentiate the effects of vinclozolin.
Finally, leucovorin is given to potentiate the effects of 5-FU in FOLFOX chemotherapy.
Co-administration of herbal remedies with cardiovascular medications with narrow therapeutic index (warfarin and digoxin) has been found to potentiate or reduce the effect of these medications [ 33].
Caffeine is known to potentiate the effect of DNA damaging agents.
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