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Four of the 15 compounds (CB20, SP46, SP50 and TT3) were found to inhibit the migration of B9.1 cells up to 55%.
In vitro, butein was found to inhibit the migration of B16F10 cells in a concentration-dependent manner using transwell and scratch assays.
In the course of screening libraries of ca. 12000 total compounds for cell migration inhibitors using a wound-closure assay, cardiac glycosides were found to inhibit the migration of the human triple-negative breast cancer cell line MDA-MB-231 at submicromolar concentrations.
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Indeed, sema3F and sema3B have been found to inhibit the adhesion, migration and proliferation of several types of lung cancer derived tumor cells [13], [14], [16], [18].
NO has previously been found to inhibit the PDGF-induced migration of fibroblasts and pericytes [55] and to inhibit the trans-endothelial migration of T cells [56], but likely acts in cell specific fashion through a variety of downstream molecular mediators.
Moreover, G-1 has been found to inhibit the chemoattractant-induced migration of SKBr3 and MCF7 cells.
In addition, CF172 was found to inhibit the SDF1-induced migration activity of SJCRH30 cells in vitro.
In addition, knockdown of ADAM10 by RNAi was found to inhibit the CNE‐2 cell proliferation and migration.
Finally, consistent with Etk's role in cellular movement and as a co-activator of FAK, CTN06 was found to inhibit migration of prostate cancer cells.
Subsequently, SLIT2 was found to inhibit leukocyte migration in the gradient of monocyte chemotactic protein-1 (MCP-1) in an in vitro pancreatic cancer model [ 87].
KAaH1 is active on Kv1.1 and Kv1.3 and was found to inhibit migration and adhesion of U87 cells whereas KAaH2 which is slightly active only on Kv1.1 channel, inhibits their proliferation via the EGFR signaling pathway.
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