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One of these is the redundant rule pruning, which scans again the set of rules found to delete the extensions of a rule that follow the rule itself, and that therefore are never applied [8].
A small loss of 4q31.2, exclusively in 8% of t-AML (tables 7 and 8) was found to delete the 5' half of SMAD1.
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Different genes, located as the c-Ha-ras gene on the short arm of chromosome 11, were also found to be deleted suggesting that the deletion of other genes could play a role in aggressiveness of head and neck carcinomas.
Thus, exons 1 2 were found to be deleted in two tumors (1.4%) and exons 21 23 deleted in one (0.7%) sample (Fig. 1).
A consensus region found to be deleted in all the tumours with 3p deletions was defined by markers D3S1286 and D3S1295, i.e. 3p25.3-p14.3, distal to the FHIT gene.
Back in the early 1990s, Vogelstein and colleagues suggested that a gene called DCC (for Deleted in Colorectal Cancer) could be a tumour suppressor gene because it was found to be deleted in more than 70% of colorectal cancers, as well as in many other cancers.
The involvement of miRNAs in cancer was first discovered in a quest to identify tumor suppressors in the frequently deleted 13q14 region in chronic lymphocytic leukaemia (CLL), and the miRNA cluster miR-15a-miR-16-1 was found to be deleted or downregulated via epigenetic silencing in 69% of the patients [ 42].
The minimal region of 1p35-36 was found to be deleted in more than 50% HCC patients.
The NSABB urged that a way be found to make deleted material available to legitimate researchers.
Added to this data controversy, Facebook has been found to have deleted messages that Zuckerberg and other senior executives sent to some users, as TechCrunch's Josh Constine reported this week.
As shown in Figure S1 (supplemental data), RD4 was found to be deleted in the genome of almost all isolates recently collected, whatever the area of collection.
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