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Interestingly, the spt16 -E857K allele, which we found to confer a dominant negative effect on SER3 repression, was previously isolated as a dominant suppressor of the transcription defects of δ element insertions just 5′ of both the LYS2 and HIS4 genes (O'Donnell et al. 2009; Stevens et al. 2011).
Only one genetic variant was found to confer a protective effect following radiotherapy.
The alleles of this complex have been found to confer a predisposing effect, a neutral effect, or a protective effect in rheumatoid arthritis [ 24].
ANP has also been found to confer anti-inflammatory effects by inhibiting nuclear factor (NF -κB activatioNF -κBcytokine production [15]-[17].
Curcumin possesses two phenyl methoxy groups (-OCH3) in its chemical structure and it was found to confer the most active suppressive effect against NF-κB activation.
In that study, mutations in several DNA repair genes were found to confer increases in the rate of spontaneous translocation similar to that conferred by the est2Δ allele, but had distinct effects on DSB-stimulated translocation.
This suggests that there are several putative binding sites for transcription factors that confer a negative effect on PGC-1α promoter activity.
Recreational use impacts were found to have a negative effect on hiking experiences in natural areas.
For example, PTEN confers a negative effect on neural stem cell self-renewal and proliferation [39], [40].
Captions were found to have a significant negative effect on learner performance.
Major arterials are found to have a double negative effect on pedestrian safety.
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