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Moreover, consistent with its stressor-specific role, selective MeA lesioning has been found to block the activation of hypothalamic paraventricular neuroendocrine cell responses to acute restraint (9) and the increase in corticosterone in response to predator odor in rats (10).
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For instance, activation of Smad2, Smad3, and Smad4 by activin and TGF-β was found to block STAT5-mediated activation of β-casein and cyclin D1 expression via inhibition of the association between STAT5 and the co-activator CBP [ 43].
PRR37 was found to block CO-mediated floral activation in long days.
CO was found to block an early step in LPS-induced NF-κB activation.
In this study, we also found that PTX did not block the activation of ERK1/2 by EGF (Additional file 1: Figure S1F).
We found that blocking the activation of VEGF receptor resulted in changes in intra-tumoral cytokine levels, specifically IL-1β, IL-6 and CXCL1.
Reassuringly, there are experimental drugs available that can block the activation of microglia.
CHS-111 was subsequently found to reduce levels of active GTP-bound RhoA by blocking the activation of the RhoA-specific GEF Vav.
In vitro studies found that pretreatment of chondrocytes with ASU blocked the activation of COX-2 transcripts and secretion of prostaglandin E2 (PGE2) to baseline levels after activation with lipopolysaccharide (LPS).
Catalase pretreatment also partially blocked the activation of caspase-3.
Thus, BCTC is able to block polymodal activation of gpTRPV1.
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