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We focused on Lipocalin2 (Lcn2), a protein recently found to be upregulated in several neuroinflammatory contexts.
MiR-34a is generally thought to be a tumor suppressor, however in our study and others, it has been found to be upregulated in several cancers including renal cell carcinoma [74], colon cancer [67] and hepatocellular carcinoma [75].
Importantly, five of these genes have been found to be upregulated in several different melanoma microarray studies.
Wnt5a has been found to be upregulated in several solid tumors, such as gastric cancer [ 17] and skin cancer [ 18].
The protein had been found to be upregulated in several MDR cell lines (Flens et al, 1997) and appeared to be widely expressed in normal human tissues.
We note the above observations with interest, as hnRNP K has a role in tumorigenesis and its expression has been found to be upregulated in several other cancers, including those of lungs and liver (Carpenter et al, 2006a).
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Various genes involved in inflammation were found to be upregulated in TCC senescence, including several CXC chemokines: IL-8, CCL3, CCL2, and CXCL10.
Of note was the upregulation of EGR-1, previously found to be upregulated in the adipose tissue of FCHL patients, the upregulation of DCHR-7, the downregulation of LYPLA2, and the differential expression of several genes previously unrelated to FCHL.
Several EMT-associated genes were found to be upregulated in the suspended cells.
In addition, genes encoding several pro-inflammatory cytokines were found to be upregulated in their expression, including IFNγ, TNFα, IL-1β and IL-6.
The deregulation of circadian gene expression extends to several genes involved in amino acid metabolism, which we found to be upregulated in the liver of CD38-deficient mice.
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found to be deregulated in several
found to be expressed in several
found to be upregulated in aged
found to be upregulated in long
found to be amplified in several
found to be dysregulated in several
found to be altered in several
found to be presented in several
found to be activated in several
found to be upregulated in 3-week-old
found to be repressed in several
found to be upregulated in osteoarthritic
found to be upregulated in diseased
found to be upregulated in psoriatic
found to be raised in several
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