In support of the relevance and potential effect of such a strategy, ephrin-A1 and several EphA receptors were found to be upregulated in active lesions of multiple sclerosis patients (Sobel, 2005).
Interestingly, miR-326 has also been found to be upregulated in peripheral blood leukocytes (PBL) of patients with relapsing remitting multiple sclerosis when compared to age-matched controls [ 27].
Multiple miR-125b targets were found to be upregulated in hepatocellular carcinoma, including BCL2, BCL2 like 2 (Bcl-W), myeloid cell leukemia sequence 1 (Mcl-1), interleukin-6 receptor (IL6R), lin-28 homolog B (LIN28B) and placenta growth factor (PIGF).
We focused on Lipocalin2 (Lcn2), a protein recently found to be upregulated in several neuroinflammatory contexts.
MMP-9 is a protease found to be upregulated in virtually all malignant tumors.
The growth arrest-specific 2 (GAS2) was cloned and found to be upregulated in the feces of recurrent CRC patients.
MiR-24 is found to be upregulated in differentiated cells.
Actually, many genes have been found to be upregulated in the transgenic plants.
Another representative of the CDKis found to be upregulated in BCL11B-transduced cells is CDKN1C (p57/Kip2).
RAGE expression was found to be upregulated in diabetic animals.
GRIA2 was found to be upregulated in chemosensitive tumours.
