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More than 40 osteogenesis-related genes were found to be upregulated in long term cocultures at four weeks.
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We focused on Lipocalin2 (Lcn2), a protein recently found to be upregulated in several neuroinflammatory contexts.
MMP-9 is a protease found to be upregulated in virtually all malignant tumors.
The growth arrest-specific 2 (GAS2) was cloned and found to be upregulated in the feces of recurrent CRC patients.
miR-1246 was found to be upregulated in M2 macrophages when treated with the exosomes fraction but not the proteins fraction (Supplementary Fig. 3c).
As expected, AKT phosphorylation (pAKT S473) was found to be upregulated in DU145 cells after PTEN depletion as well as in PTEN knockout PC3 cells (Supplementary Figure S4A).
ASB2 and RARA were two proteins found to be upregulated in all-trans-retinoic acid (ATRA -induced differentiATRA -inducedemia cells76,77.
Inflammatory cytokines such as interleukin-33 (IL-33), chemokine ligand 4 (CCl-4) are also found to be upregulated in scar Fb.
MiR-24 is found to be upregulated in differentiated cells.
Actually, many genes have been found to be upregulated in the transgenic plants.
Another representative of the CDKis found to be upregulated in BCL11B-transduced cells is CDKN1C (p57/Kip2).
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