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Transglutaminase 2 (TG2) and its phosphorylation have been consistently found to be upregulated in a number of cancer cell types.
Interestingly, IRAK1 is another component of the IL1R-JNK pathway (Vig et al., 1999) and has been recently found to be upregulated in a mouse model of Rett syndrome (Urdinguio et al., 2008).
This shows a strong parallel to results obtained in Streptococcus pyogenes, where the transcription of these genes was found to be upregulated in a Rel-independent manner upon an artificially induced amino acid starvation [ 43].
Bcl-2 has been found to be upregulated in a series of tumor types including squamous cell carcinomas of the lung and the potential of Bcl-2 to predict survival for NSCLC patients has been assessed by immunohistochemistry, with different studies demonstrating varying degrees of correlation between Bcl-2 expression and outcome [ 19- 28].
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Hsf1 was very recently found to be upregulated in A. fumigatus under heat shock [ 18].
Here, it was found to be upregulated in SMZL cases, a tumor that lacks BCL6 expression.
MMP-9 is a protease found to be upregulated in virtually all malignant tumors.
SOD2 an antioxidant was found to be upregulated in LEC, limbus and cornea (table 3).
The growth arrest-specific 2 (GAS2) was cloned and found to be upregulated in the feces of recurrent CRC patients.
MiR-24 is found to be upregulated in differentiated cells.
Actually, many genes have been found to be upregulated in the transgenic plants.
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