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These mutant forms, as well as the wild-type PTEN, were used to complement XTC.UC1 cells; XTC.UC1 is a cell line established from a metastasis of thyroid oncocytic follicular carcinoma [ 10], which we found to be null for PTEN (Additional file 1: Figure S1).
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I θ r θ s * is found to be a null row vector, thus, I − 1 θ ^ 1 θ r θ r * − 1 = I θ r θ r *.
More unexpectedly, an increasing number of rare genetic diseases are being found to be caused by null alleles of genes encoding Golgi proteins.
The EJP frequency of spontaneous miniature EJPs (mEJPs) were found to be lower in endoA null mutant larvae than in controls [5].
There is, however, no overlap with the genes found to be altered in Htt null cell lines [ 47], although this could be the result of the very different biological systems studied and the different chips used.
The constraint of fixed row and column totals has been debated elsewhere in the context of species co-occurrence patterns, where it was found to be most appropriate in null model comparisons, although critics have argued earlier that these marginals themselves may already reflect competitive interactions ([ 46] and references therein).
HFE null mice were found to be phenotypically identical to BMP2-null mice [ 36].
Levels of tryptophan, tyrosine, hydroxyproline and β-alanine were found to be reduced in CD38-null mice, whereas asparagine, glycine, histidine and methionine were elevated.
If the analysis is found to be statistically significant, then the null hypothesis is rejected for the alternative hypothesis.
Because TGF-β stimulates myofibroblasts differentiation, and as myofibroblasts accumulation was found to be attenuated in Egr-1 null mice [26].
Predictors found to be significantly different from the null model were then considered for inclusion in an overall model.
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