Sentence examples for found to be inactivated in many from inspiring English sources

Beside p53, PTEN is the most important tumor suppressor and found to be inactivated in many human cancers [15], [17].

pRb acts as a repressor of E2F-directed cell proliferation; pRb has been found to be inactivated in many cancers (reviewed in [ 39]).

Interestingly, p16 has been found to be inactivated in NSCLC tumors from nonsmokers only through promoter hypermethylation [ 133].

The deleted in liver cancer 1 (Dlc1) gene encodes a RhoGTPase activating protein (RhoGAP) that has been found to be inactivated by deletion or promoter methylation in many tumours, resulting in alterations in cellular proliferation, cytoskeleton reorganization and gene expression in tumour cells [ 8- 15].

Indeed, the mechanisms by which the apoptotic pathway is inactivated in many cancers are similar to those seen in postmitotic cells.

The WWOX tumor suppressor gene is inactivated in many types of human cancers by genomic rearrangements, aberrant mRNA splicing, homozygous deletions and epigenetic silencing [1] [5], [24].

CDKN2A/p16 INK4A was originally identified as a melanoma susceptibility gene (38), but is inactivated in many tumors including lung cancer (39– 42).

Since wt p53 is a critical tumor suppressor gene, it is inactivated in many human cancers [ 23].

Phosphatase and tensin homologue deleted in chromosome 10 (PTEN) is a tumour suppressor protein that is inactivated in many human cancers (Georgescu, 2010).

Phosphatase and tensin homologue (PTEN) is a tumor suppressor gene which is inactivated in many different tumors, including prostate cancer [ 113].

Eleven years ago, the first targeted therapies that reactivate a protein called p53, which is inactivated in many cancer cells, were developed.