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All other introns are found to be gained or lost only within a single restricted subgroup or in only a single gene.
Also the 1q and 3q arms, often found to be gained [ 7, 10, 21, 24- 26], were overrepresented in 5 of the 10 cell lines.
Chromosome arms that were found to be gained and/or amplified in most of the cell lines by array CGH in this study were 5p, 8p, 8q, 9p, 9q, 17q and 20q.
Our co-duplication analysis found higher than expected numbers of co-duplicating genes, yet genes in known genetic modules were not always found to be gained and lost together.
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Most of these alterations have been found to be gain-of-function mutations.
Of note, no R-segments were found to be preferentially gained in primary relative to metastatic melanomas and no regions of loss were significantly different between primary and metastasis.
At a false discovery rate (FDR) of 10% (q< = 0.1), 300 R-segments spanning 32 contiguous regions of interest (ROIs) were found to be preferentially gained in metastatic relative to primary melanomas in a non-random fashion (Figure 2B).
First, we selected the chromosome arms that were found to be recurrently gained or lost by GISTIC in [ 10].
In the scenario analyses which compared initiating dabigatran before age 80 with treatment with aspirin, the ICER was found to be £3457/QALY gained, while dabigatran dominated receiving no thrombophylaxis (ie, more effective and less costly).
And indeed, I found something to be gained by occasionally removing my headphones and enjoying the exotic music of this rarely heard tongue.
The most frequent aberration was found to be a gain on 3q, observed in 21 out of the 23 patients (91%), more precisely the loci 3q25 q27 in 20 of the 23 of the PT (87%), and 21 of the 23 LNM (91%).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com