Few genes have been found to be frequently down-regulated in these tumours, and even fewer to carry frequent mutations (Liu and Ganesan, 2002).
For example, the promoter of the TERT telomerase gene has been found to be frequently mutated in cancer42,43, allowing this gene to be clearly implicated by WGS.
A minimal region of 8p21-22 was found to be frequently deleted in HCC.
For boreal summer, tropical cyclogenesis was found to be frequently related to ISV activities (Kikuchi and Wang [2010]).
Conversely, miR-181b has been found to be frequently downregulated in CRC samples due to higher hypermethylation and exert tumor-suppressive effects (Zhao et al., 2016).
Genes involved in oxidative stress response and squamous differentiation pathways were found to be frequently altered by mutation or copy number alteration or up-/down- regulation in squamous cell lung cancer [27].
In HCC, TP53 was also found to be frequently mutated, and the common risk factors such as AFB1, HBV, and HCV are reported to cause TP53 mutation (Hussain et al., 2007; Ozturk, 1991).
In the past several years, protein components of the SWI/SNF complex have been found to be frequently inactivated in cancer, and subsequent work has solidified their status as bona fide epigenetic tumor suppressors (Wilson and Roberts, 2011).
Marketers have successfully advertised in locations that the current study found to be frequently used impersonal external information sources exposure in fashion magazines and catalogs, and interesting store displays for visual merchandising.
A serine/threonine kinase SGK3, which shares great similarity with AKT, was found to be frequently amplified and confer AKT-independent oncogenic roles in HCC (Liu et al., 2012).
This index was also found to be frequently correlated with the fourth r-SVs.
