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The phosphorylation and subsequent activation of Stat3, a member of the STAT family, has been found to be elevated in a large number of diverse human cancers.
Importantly, extracellular versican has been found to be elevated in a variety of human tumors including breast carcinoma [ 41– 41].
ADAM9 expression was found to be elevated in a cell line having high metastatic potential as compared to cell lines that had a low metastatic potential [ 35].
However, TIGAR expression has been found to be elevated in a number of cancer models and tumour types through a mechanism that is not dependent on the maintenance of wild-type (WT) p53.
Further, serum levels of soluble CD40L have been found to be elevated in a variety of autoimmune conditions, including SLE, RA, Sjögren's syndrome, and inflammatory bowel disease, and were correlated to autoantibody titers and disease activity [ 191, 194].
Urinary total hCG levels were found to be elevated in a subgroup of patients referred for cystoscopy who were found to have bladder cancer but none of those with benign conditions.
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The proteoglycan synthesis was found to be elevated in all cartilage surfaces.
Elevated plasma endothelial microparticle levels have been found to be elevated in women with preeclampsia.
Notably, Oct4 mRNA has been found to be elevated in patients with class 1 disease9.
Peripheral and cerebrospinal fluid levels of pro-inflammatory cytokines have been found to be elevated in migraineurs [27 29].
Plasma sphingosine-1-phosphate levels were found to be elevated in rat and mouse models of diabetes [36].
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